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Prof. Adnan A. Bekhit

Professor

Allied Health
17435828
S121
abekhit@uob.edu.bh

Areas of Expertise

Molecular modeling, computer-aided drug design (CADD), molecular mechanics, and other bioinformatics applications were employed to create and synthesize innovative agents targeting persistent health issues such as inflammation and infection, as well as rare and neglected diseases like leishmaniasis and malaria, and newly emerged diseases like COVID-19. Moreover, he has made contributions to food safety and explored food by-products as potential sources of valuable pharmaceuticals. Additionally, his research involved the design of novel drug delivery systems using functional biomaterials in collaboration with Harvard University, USA.

Education

  • 1993, Ph.D. in Pharmaceutical Chemistry, thesis titled “Synthesis of some quinazoline derivatives of potential therapeutic activity (anti-inflammatory)”. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
  • 1989, M. Pharm. in Pharmaceutical Chemistry, thesis titled “ Synthesis of some quinazoline derivatives of potential therapeutic activity (anti-inflammatory, antimicrobial, anticonvulsant) ” Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
  • 1984, B. Pharm. Sci. with general grade distinction honor, Faculty of Pharmacy, University of Alexandria, Egypt.

Biography

Prof. Adnan A. Bekhit earned his M Pharm in 1989 and Ph.D. in Pharmaceutical Chemistry in 1993 from Alexandria University, Egypt. He conducted postdoctoral research at SAIC-NCI-FCRDC in the USA and Kyoto Pharmaceutical University, Japan. Currently, he is a professor at Alexandria University and an honorary visiting professor at Kyoto Pharmaceutical University. Since 2018, he has been with the College of Health & Sport Sciences at the University of Bahrain. His research focuses on designing and synthesizing novel bioactive compounds, including anti-inflammatory, antimicrobial, and anticancer agents. He has published 145 papers, with an H-index of 41, highlighting his impact in medicinal chemistry.

Achievements

  • Alexandria University publication awards, 2005-2024.
  • Alexandria University Honorary Award, Egypt, 2016.
  • Unilever Mashreq Best Scientific Paper Award, Egypt, 2015.
  • Distinguished Research Professor in Medical Sciences, Alexandria University, Egypt, 2015.
  • Alexandria University Award for Administrative Excellence, 2015.
  • Outstanding contribution in Reviewing Award for Eur. J. Med. Chem., 2015.
  • Outstanding contribution in Reviewing Award for Eur. J. Med. Chem., 2014.
  • Youssef Jameel Prize for Scientific Excellence, 2010.
  • Publication Medal, Alexandria University, Egypt, 2010.
  • Alexandria University Prize for Scientific Promotion, 2004.
  • Silver Medal for Merit, General Egyptian Syndicate of Pharmacists, 2001.
  • Medal of Scientific Advances, Alexandrian Syndicate of Pharmacists, 2000.
  • Full Resident Scholarship to the 1999 Residential School on Medicinal Chemistry, Drew University, Madison, NJ 07940-4037, 1999.
  • Medal for Merit of the General Egyptian Syndicate of Pharmacists, 1993.
  • Arab Scientific Innovation Prize in Chemistry, Kuwait, 1992.
  • Faculty of Pharmacy Recognition Award for Social and Scientific Activities, 1984.

Affiliations

  • Japanese Peptide Society.
  • American Chemical Society, Division of Medicinal Chemistry.
  • Egyptian Pharmaceutical Society.
  • General Egyptian Syndicate of Pharmacists.
  • Scientific Society of the Faculty of Pharmacy, Alexandria University.
  • Scientific Society of Students Hospital, Alexandria University.

Grants & Contracts Awarded

  • Synthesis and evaluation of drug-polymer conjugate nanomicelles as emerging platform for targeted brain tumor therapy"", project ID no. 15053, STDF, Feb. 2015, ُEgypt.
  • Synthesis and application of novel dendrimers in medicinal chemistry, AlexRep, Jun. 2014, Egypt.
  • Synthesis and biological evaluation of some heterocyclic derivatives as antiprotozoal agents, AlexRep, Jun. 2014, Egypt.
  • Functional food analysis laboratory in Alexandria University, STDF, 4876, Nov. 2012, Egypt.

Publications & Presentations

  1. Prevalence, Attitude and Practice of Herbal Medicine in Bahrain, Nasralla, S., Habib, H., Ibrahim, A., & Bekhit, A., Indonesian Journal of Pharmacy 2024 ( In Press). https://doi.org/10.22146/ijp.9457
  2. Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine‑coupled pyrazole derivatives, Halefom Gebreselasse Berhe, Yihenew Simegniew Birhan, Botros Youssef Beshay, Huda Jawad Habib, Ariaya Hymete and Adnan Ahmed Bekhit, BMC Chemistry 18:9, (2024), https://doi.org/10.1186/s13065-023-01111-0
  3. Antimalarial and Antileishmanial Flavonoids from Calendula officinalis Flowers, Arwa A. Al-Huqail, Adnan A. Bekhit, Hammad Ullah, Muhammad Ayaz and Nada M. Mostafa, Agronomy 2023, 13, 2765. https://doi.org/10.3390/agronomy13112765
  4. Protein and Peptide-based Nanoparticles as an Emerging Strategy to Tackle Cancer Drug Resistance, Mohamed K. Abdellatif, Islam A. Hassanin, Yosra S. Mahmoud, Mohamed Teleb, Adnan A. Bekhit, Sherine N. Khattab, Alexandria Journal of Science and Technology 1(1), 1–21 (2023), DOI: 10.21608/AJST.2023.206740.1008
  5. In silico screening of SARS-CoV2 helicase using African natural products: Docking and molecular dynamics approaches, Hamada R. Knany, Sherif A. Elsabbagh, Moustafa A. Shehata, Wagdy M. Eldehna, Adnan A. Bekhit, Tamer M. Ibrahim, Virology 587, 109863 (2023), https://doi.org/10.1016/j.virol.2023.10986
  6. Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer, Yomna M. Elmorshedy, Mohamed Teleb, Marwa A. Sallam, Kadria A. Elkhodairy, Mohammed Bahey-El-Din, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Shimaa A. H. Abdel Monaim, Adnan A. Bekhit, Ahmed O. Elzoghby*, Fernando Albericio, and Sherine N. Khattab, Biomacromolecules, 24, 5, 2149–2163 (2023). https://doi.org/10.1021/acs.biomac.3c00037
  7. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies, Nayera W. Hassan, Ahmed Sabt, Maryam A.Z. El-Attar, Mikko Ora, Alaa El-Din A. Bekhit, Kikuko Amagase, Adnan A. Bekhit, Ahmed S.F. Belal, Perihan A. Elzahhar, Eur. J. Med. Chem. 253, 115333 (2023), https://doi.org/10.1016/j.ejmech.2023.115333
  8. Tetrahydrobenzo[h]quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and biological evaluation, Tamer M. Ibrahim, Ghada Abada, Marcel Dammann, Raed M. Maklad, Wagdy M. Eldehna, Rofaida Salem, Marwa M. Abdelaziz, Ramadan A. El-domany, Adnan A. Bekhit, Frank M. Beockler, Eur. J. Med. Chem., 257, 115534 (2023), https://doi.org/10.1016/j.ejmech.2023.115534
  9. Marine Fish-Derived Lysophosphatidylcholine: Properties,Extraction, Quantification, and Brain Health Application, Mirja Kaizer Ahmmed, Mayssa Hachem, Fatema Ahmmed, Ali Rashidinejad, Fatih Öz, Adnan Bekhit, Alan Carne and Alaa El-Din Bekhit, Molecules, 28, 3088 (2023), https://doi.org/10.3390/molecules28073088
  10. Engineered Sericin-Tagged Layered Double Hydroxides for Combined Delivery of Pemetrexed and ZnO Quantum Dots a s Biocompatible Cancer Nanotheranostics, Riham M. Abdelgalil, Sherine N. Khattab, Shaker Ebrahim, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Marwa A. Sallam, and Ahmed O. Elzoghby, ACS Omega, 8, 5655–5671 (2023), https://doi.org/10.1021/acsomega.2c07128
  11. New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies, Ahmed Sabt, Wagdy M. Eldehna, Tamer M. Ibrahim, Adnan A. Bekhit, Rasha Z. Batran, Eur. J. Med. Chem. 246, 114959 (2023), https://doi.org/10.1016/j.ejmech.2022.114959
  12. Combined Cancer Immunotheranostic Nanomedicines: Delivery Technologies and Therapeutic Outcomes, Tasneem A. Nasser, Rawan Adel, Abdelrahman Badr, Mohamed Teleb, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed S. Abdelhamid*, and Ahmed O. Elzoghby, ACS Omega, 8, 5, 4491–4507 (2023), DOI: 10.1021/acsomega.2c05986
  13. Engineered nano

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Prof. Adnan A. Bekhit

Professor

Allied Health
17435828
S121
abekhit@uob.edu.bh

Areas of Expertise

Molecular modeling, computer-aided drug design (CADD), molecular mechanics, and other bioinformatics applications were employed to create and synthesize innovative agents targeting persistent health issues such as inflammation and infection, as well as rare and neglected diseases like leishmaniasis and malaria, and newly emerged diseases like COVID-19. Moreover, he has made contributions to food safety and explored food by-products as potential sources of valuable pharmaceuticals. Additionally, his research involved the design of novel drug delivery systems using functional biomaterials in collaboration with Harvard University, USA.

Education

  • 1993, Ph.D. in Pharmaceutical Chemistry, thesis titled “Synthesis of some quinazoline derivatives of potential therapeutic activity (anti-inflammatory)”. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
  • 1989, M. Pharm. in Pharmaceutical Chemistry, thesis titled “ Synthesis of some quinazoline derivatives of potential therapeutic activity (anti-inflammatory, antimicrobial, anticonvulsant) ” Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
  • 1984, B. Pharm. Sci. with general grade distinction honor, Faculty of Pharmacy, University of Alexandria, Egypt.

Biography

Prof. Adnan A. Bekhit earned his M Pharm in 1989 and Ph.D. in Pharmaceutical Chemistry in 1993 from Alexandria University, Egypt. He conducted postdoctoral research at SAIC-NCI-FCRDC in the USA and Kyoto Pharmaceutical University, Japan. Currently, he is a professor at Alexandria University and an honorary visiting professor at Kyoto Pharmaceutical University. Since 2018, he has been with the College of Health & Sport Sciences at the University of Bahrain. His research focuses on designing and synthesizing novel bioactive compounds, including anti-inflammatory, antimicrobial, and anticancer agents. He has published 145 papers, with an H-index of 41, highlighting his impact in medicinal chemistry.

Achievements

  • Alexandria University publication awards, 2005-2024.
  • Alexandria University Honorary Award, Egypt, 2016.
  • Unilever Mashreq Best Scientific Paper Award, Egypt, 2015.
  • Distinguished Research Professor in Medical Sciences, Alexandria University, Egypt, 2015.
  • Alexandria University Award for Administrative Excellence, 2015.
  • Outstanding contribution in Reviewing Award for Eur. J. Med. Chem., 2015.
  • Outstanding contribution in Reviewing Award for Eur. J. Med. Chem., 2014.
  • Youssef Jameel Prize for Scientific Excellence, 2010.
  • Publication Medal, Alexandria University, Egypt, 2010.
  • Alexandria University Prize for Scientific Promotion, 2004.
  • Silver Medal for Merit, General Egyptian Syndicate of Pharmacists, 2001.
  • Medal of Scientific Advances, Alexandrian Syndicate of Pharmacists, 2000.
  • Full Resident Scholarship to the 1999 Residential School on Medicinal Chemistry, Drew University, Madison, NJ 07940-4037, 1999.
  • Medal for Merit of the General Egyptian Syndicate of Pharmacists, 1993.
  • Arab Scientific Innovation Prize in Chemistry, Kuwait, 1992.
  • Faculty of Pharmacy Recognition Award for Social and Scientific Activities, 1984.

Affiliations

  • Japanese Peptide Society.
  • American Chemical Society, Division of Medicinal Chemistry.
  • Egyptian Pharmaceutical Society.
  • General Egyptian Syndicate of Pharmacists.
  • Scientific Society of the Faculty of Pharmacy, Alexandria University.
  • Scientific Society of Students Hospital, Alexandria University.

Grants & Contracts Awarded

  • Synthesis and evaluation of drug-polymer conjugate nanomicelles as emerging platform for targeted brain tumor therapy"", project ID no. 15053, STDF, Feb. 2015, ُEgypt.
  • Synthesis and application of novel dendrimers in medicinal chemistry, AlexRep, Jun. 2014, Egypt.
  • Synthesis and biological evaluation of some heterocyclic derivatives as antiprotozoal agents, AlexRep, Jun. 2014, Egypt.
  • Functional food analysis laboratory in Alexandria University, STDF, 4876, Nov. 2012, Egypt.

Publications & Presentations

  1. Prevalence, Attitude and Practice of Herbal Medicine in Bahrain, Nasralla, S., Habib, H., Ibrahim, A., & Bekhit, A., Indonesian Journal of Pharmacy 2024 ( In Press). https://doi.org/10.22146/ijp.9457
  2. Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine‑coupled pyrazole derivatives, Halefom Gebreselasse Berhe, Yihenew Simegniew Birhan, Botros Youssef Beshay, Huda Jawad Habib, Ariaya Hymete and Adnan Ahmed Bekhit, BMC Chemistry 18:9, (2024), https://doi.org/10.1186/s13065-023-01111-0
  3. Antimalarial and Antileishmanial Flavonoids from Calendula officinalis Flowers, Arwa A. Al-Huqail, Adnan A. Bekhit, Hammad Ullah, Muhammad Ayaz and Nada M. Mostafa, Agronomy 2023, 13, 2765. https://doi.org/10.3390/agronomy13112765
  4. Protein and Peptide-based Nanoparticles as an Emerging Strategy to Tackle Cancer Drug Resistance, Mohamed K. Abdellatif, Islam A. Hassanin, Yosra S. Mahmoud, Mohamed Teleb, Adnan A. Bekhit, Sherine N. Khattab, Alexandria Journal of Science and Technology 1(1), 1–21 (2023), DOI: 10.21608/AJST.2023.206740.1008
  5. In silico screening of SARS-CoV2 helicase using African natural products: Docking and molecular dynamics approaches, Hamada R. Knany, Sherif A. Elsabbagh, Moustafa A. Shehata, Wagdy M. Eldehna, Adnan A. Bekhit, Tamer M. Ibrahim, Virology 587, 109863 (2023), https://doi.org/10.1016/j.virol.2023.10986
  6. Engineered Microencapsulated Lactoferrin Nanoconjugates for Oral Targeted Treatment of Colon Cancer, Yomna M. Elmorshedy, Mohamed Teleb, Marwa A. Sallam, Kadria A. Elkhodairy, Mohammed Bahey-El-Din, Doaa A. Ghareeb, Shaymaa A. Abdulmalek, Shimaa A. H. Abdel Monaim, Adnan A. Bekhit, Ahmed O. Elzoghby*, Fernando Albericio, and Sherine N. Khattab, Biomacromolecules, 24, 5, 2149–2163 (2023). https://doi.org/10.1021/acs.biomac.3c00037
  7. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies, Nayera W. Hassan, Ahmed Sabt, Maryam A.Z. El-Attar, Mikko Ora, Alaa El-Din A. Bekhit, Kikuko Amagase, Adnan A. Bekhit, Ahmed S.F. Belal, Perihan A. Elzahhar, Eur. J. Med. Chem. 253, 115333 (2023), https://doi.org/10.1016/j.ejmech.2023.115333
  8. Tetrahydrobenzo[h]quinoline derivatives as a novel chemotype for dual antileishmanial-antimalarial activity graced with antitubercular activity: Design, synthesis and biological evaluation, Tamer M. Ibrahim, Ghada Abada, Marcel Dammann, Raed M. Maklad, Wagdy M. Eldehna, Rofaida Salem, Marwa M. Abdelaziz, Ramadan A. El-domany, Adnan A. Bekhit, Frank M. Beockler, Eur. J. Med. Chem., 257, 115534 (2023), https://doi.org/10.1016/j.ejmech.2023.115534
  9. Marine Fish-Derived Lysophosphatidylcholine: Properties,Extraction, Quantification, and Brain Health Application, Mirja Kaizer Ahmmed, Mayssa Hachem, Fatema Ahmmed, Ali Rashidinejad, Fatih Öz, Adnan Bekhit, Alan Carne and Alaa El-Din Bekhit, Molecules, 28, 3088 (2023), https://doi.org/10.3390/molecules28073088
  10. Engineered Sericin-Tagged Layered Double Hydroxides for Combined Delivery of Pemetrexed and ZnO Quantum Dots a s Biocompatible Cancer Nanotheranostics, Riham M. Abdelgalil, Sherine N. Khattab, Shaker Ebrahim, Kadria A. Elkhodairy, Mohamed Teleb, Adnan A. Bekhit, Marwa A. Sallam, and Ahmed O. Elzoghby, ACS Omega, 8, 5655–5671 (2023), https://doi.org/10.1021/acsomega.2c07128
  11. New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies, Ahmed Sabt, Wagdy M. Eldehna, Tamer M. Ibrahim, Adnan A. Bekhit, Rasha Z. Batran, Eur. J. Med. Chem. 246, 114959 (2023), https://doi.org/10.1016/j.ejmech.2022.114959
  12. Combined Cancer Immunotheranostic Nanomedicines: Delivery Technologies and Therapeutic Outcomes, Tasneem A. Nasser, Rawan Adel, Abdelrahman Badr, Mohamed Teleb, Adnan A. Bekhit, Kadria A. Elkhodairy, Ahmed S. Abdelhamid*, and Ahmed O. Elzoghby, ACS Omega, 8, 5, 4491–4507 (2023), DOI: 10.1021/acsomega.2c05986
  13. Engineered nano

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